Endocrine Abstracts

Graves’ orbitopathy (GO) is an inflammatory autoimmune disorder of the orbit. The close clinical and temporal relationships between Graves’ hyperthyroidism and GO suggest that both conditions derive from a single systemic process and share the thyrotropin receptor (TSHR) as autoantigen. Autoimmunity directed against the TSHR on orbital fibroblasts sets in motion connective tissue remodeling within the orbit that leads to the various clinical expressions of the diseas...